MNF Bills vs. Falcons Week 6 Fantasy Football Start ‘Em Sit ‘Em picks ft. Drake London, Keon Coleman, James Cook

Week 6 of the 2025 fantasy football season concludes with a Monday Night Football doubleheader. The first game will be a matchup between the Buffalo Bills and the Atlanta Falcons. Both teams feature plenty of potential lineup options, but here are the best options to target and fade based on their overall situations.

Bills vs Falcons MNF Fantasy Football Week 6 Starting Picks

The Atlanta Falcons have selected Drake London as their primary pass target and have relied on him to handle a heavy workload. Through four games, he averaged six receptions on nine targets, also setting a season-best performance. His most recent games included season highs across the board, and given a potential pass-heavy program for the Falcons to keep up with the Buffalo Bills, London is an excellent option for Week 6 lineups.

James Cook is another solid pick this week after his impressive start to the 2025 fantasy football season. He has finished among the top 10 weekly running backs in four of his five games so far, and currently ranks as a top RB8 ahead of Monday Night Football. He has been a clear workhorse for the Bills this year with at least 15 touches per game, making him very reliable.

It should start

• Josh Allen
• Bijan Robinson
• James Cook
• Drake London

DFS picks

Bills vs Falcons MNF Fantasy Football Week 6 Picks Sit ‘Em

Sportskeeda’s ‘Who Should I Start’ tool provides managers with one of the best ways to improve their weekly lineups. It generates fantasy projections and lineup suggestions for any player in a given week by carefully taking all their current positions into consideration. Managers who use them often gain an advantage over the rest of the league.

Keon Coleman is recommended for fadeaways this week due to his unreliable size and inconsistent results. He proved in his first game of the year that he is an upside in a productive Bills offense by finishing as a weekly WR4, but has failed to finish in the weekly top 40 receiver list in each of his four games since. The Falcons also allow the fourth-fewest fantasy points per game to receivers, so managers should avoid using Coleman this week.

He must sit down

• Tyler Alger
• Ray Davis
• Ty Johnson
• Curtis Samuel
• Josh Palmer
• Ray Ray McCloud III

DFS fades

• Michael Penix Jr
• Dalton Kincaid